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fabHB [2017-8-11 16:0:3]
beta-ketoacyl-acyl carrier protein synthase III
function
fatty acid biosynthesis
product
beta-ketoacyl-acyl carrier protein synthase III
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids]Gene
Coordinates
1,092,770 → 1,093,747
The protein
Catalyzed reaction/ biological activity
Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacyl-[acyl-carrier-protein] + CoA + CO2 (according to Swiss-Prot)Protein family
fabH family (according to Swiss-Prot)Paralogous protein(s)
[protein|40E064365588CFED483FBFED02BFC0DA531CCC4A|FabHA], one of the two proteins has to be present for viability [Pubmed|17114254]Structure
[PDB|1EBL] (FabH from ''E. coli'') [Pubmed|10673437][SW|Localization]
cytoplasm (according to Swiss-Prot)Additional information
affinity for butyryl-CoA, but prefers acetyl-CoA in fatty acid biosynthesis [Pubmed|19820084]Expression and Regulation
Operons
genes
[gene|FC818B3A8A3080231C1F8DE95377325C8E754DCE|fabHB]
description
[Pubmed|12737802]
regulatory mechanism
[protein|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR]: repression, [Pubmed|12737802], in [regulon|FCDE900167AE36377979E0CF7BC33C7F351B95D3|FapR regulon]regulation
induced if the cells experience a lack of malonyl-CoA ([protein|search|FapR]) [Pubmed|12737802]view in new tabReferences
Reviews
Original Publications
12737802,17114254,10629181,10673437,19820084,21383089,25196128 
